Unlike the synthetic filler concept, Human Solid Plasma aims to form a biocompatible, additive-free, and entirely autologous protein matrix. On this page you will find a technical explanation of HSP's biological foundations.
What is a Biological Matrix?
In tissue engineering and regenerative medicine, "matrix" means a three-dimensional scaffold on which cells can live, proliferate, and organize.
The biological matrix approach aims to provide a protein environment that cells naturally recognize, instead of providing them with an artificial substance. HSP is a concrete example of this philosophy.
Biochemical Foundation of HSP
The Role of Plasma Proteins
There are hundreds of different proteins in human plasma. Among them, the most abundant is albumin (approximately 60% of total plasma protein).
The basic principle of HSP is to convert these plasma proteins into a semi-solid (solid) form through controlled heat denaturation.
Controlled Heat Denaturation
When proteins are exposed to heat, they undergo a structural change above a certain point; this process is called denaturation. A classic example is the solidification of egg white as it is cooked.
In the HSP device, this process is carried out with controlled parameters: temperature, duration, and homogenization are precisely managed.
Pure and Additive-Free Process
No external chemicals are added in HSP production. There are no anticoagulants (heparin, citrate), stabilizers, preservatives, or similar additives.
Philosophical Difference from Synthetic Filler
There are two main philosophies in modern aesthetic medicine:
- 1) Synthetic approach: Complete what is missing by adding it from outside.
- 2) Regenerative approach: Support the tissue's own repair capacity.
HSP is the representative of the second philosophy.
Basic Features
- 100% autologous structure
- No anticoagulants
- No external chemical additives
- Forms pure plasma-serum protein matrix
- Semi-solid form
- Biologically active protein scaffold
- Patented invention technology
Mechanism of Action Detail
A. Physical Support (Volume)
The semi-solid form instantly provides physical volume within the tissue.
B. Cellular Scaffold
The protein matrix serves as a structural scaffold for surrounding cells.
C. Micro-Regenerative Stimulation
The presence of a semi-solid protein within the tissue can be associated with local cellular responses.
D. Collagen Synthesis Support
An increase in fibroblast activity can lead to triggered collagen production.
E. Tissue Perfusion Support
Support of new vessel formation (angiogenesis) can improve tissue perfusion.
Clinical Meaning
The practical meaning of HSP's biological matrix approach for physicians:
- Not an alternative to synthetic filler; an independent biological approach
- Patient counseling is easier — patients are more open to autologous approach
- Multidisciplinary use opportunity
- Low side effect profile — thanks to autologous structure
- Sustainable / repeatable protocol
- Compatible with modern regenerative medicine paradigm