What is HSP?

Human Solid Plasma (HSP) is an innovative biological matrix approach based on the principle of converting the patient's own plasma-serum proteins, especially the albumin fraction, into a semi-solid form through controlled heat denaturation.

Unlike the synthetic filler concept, HSP aims to form a biocompatible, additive-free, and entirely autologous protein matrix. The resulting solid plasma is not just a volume-providing material; it is a biologically active protein scaffold that can support cellular response.

Key Features

• 100% autologous structure — Obtained entirely from the patient's own blood. Contains no animal source, synthetic polymer, or artificial substance.
• No anticoagulants — No heparin, citrate, or similar clotting inhibitors are used.
• No external chemical additives — No substances other than plasma are added during the production process.
• Pure plasma-serum protein matrix — The output offers a biological scaffold composed of natural proteins.
• Biologically active — Not an inert material that only provides volume; an active matrix that can support cellular response.
• Semi-solid form — A controlled form that can stay longer within the tissue compared to liquid plasma.

How is HSP Different from Synthetic Filler?

Traditional synthetic filler materials (hyaluronic acid, collagen, calcium hydroxylapatite, etc.) are externally added, foreign substances. While this approach has certain advantages, there are significant differences:

• Source: Synthetic filler → external source; HSP → patient's own blood
• Function: Synthetic filler → volume providing; HSP → both volume and biological stimulation
• Content: Synthetic filler → single-type molecule; HSP → multiple plasma proteins
• Reaction risk: Synthetic filler → hypersensitivity possibility; HSP → autologous structure (minimal allergic risk)
• Sustainability: Synthetic filler → repeated injections; HSP → biological process support

How is HSP Different from PRP?

Although there are some similarities between HSP and PRP (Platelet-Rich Plasma), there are fundamental differences:

• PRP: Platelet-rich plasma; liquid form; relies on the biological effect of growth factors.
• HSP: Albumin-weighted protein matrix; semi-solid form; provides biological support and volume as a protein scaffold.
• Combined use potential: In some protocols, HSP can be evaluated in combined biostimulation approach with PRP.

Mechanism of Action

HSP can produce a multifaceted biological effect in the area where it is applied. These mechanisms are defined at the hypothetical level based on experimental and clinical observations and evaluated under physician supervision:

1. Temporary Volume Support

Thanks to the semi-solid form, an immediately palpable volume is created in the application area, but not stiff like an artificial filler.

2. Micro-Regenerative Stimulation

Micro-level stimulations are created within the tissue through the protein matrix. These stimulations can activate local cellular responses.

3. Collagen Synthesis Support

There is biological logic suggesting that fibroblast activity and collagen production are supported.

4. Tissue Perfusion

Support of new vessel formation (angiogenesis) can improve the tissue's nutrition and oxygenation.

5. Cellular Microenvironment

The protein matrix offers an appropriate biological microenvironment for cells.

Clinical Advantages

• 100% autologous biological structure — minimal allergic reaction risk
• Contains no heparin, citrate, or additive chemicals
• Not a synthetic filler alternative — it is a biological matrix approach, an independent category
• Compatible with regenerative medicine
• Can be integrated into aesthetic and therapeutic application areas
• Fast preparation process
• Low side effect profile

For Which Patients Should It Be Considered?

HSP is considered as a support/alternative option for patients deemed suitable as a result of physician evaluation. Generally, it can be considered in the following situations:

• Patients who prefer a biological approach instead of synthetic filler
• Those who want skin rejuvenation (dermatology/medical aesthetics)
• Patients with slow chronic wound healing (with physician evaluation)
• Patients seeking postmenopausal gynecological support
• Clinical conditions where tissue regeneration support may be considered

Contraindications

As with every medical application, individual contraindications are reviewed during physician evaluation in HSP.