Human Solid Plasma offers support with a biological protein matrix approach in diabetic foot and chronic soft tissue wounds. It is evaluated as a complementary component in regenerative wound care protocols.
Clinical Picture: What is a Chronic Wound?
Chronic wounds are wounds that exceed the normal time period and do not heal with standard care. Generally, wounds that have not shown healing for more than 4-6 weeks are evaluated in this category.
Diabetic foot wounds, pressure wounds, and venous or arterial stasis ulcers are the most common types of chronic wounds.
Pathophysiology
The basic biological problems preventing healing in chronic wounds:
- Microcirculation impairment — Inadequate tissue perfusion
- Insufficient collagen production — Reduced collagen synthesis
- Delayed epithelialization — Slowed new skin cell production
- Chronic inflammation environment
Expected Contributions of HSP
HSP is a biological matrix approach that can support this pathophysiological picture with multiple mechanisms:
- Formation of biological protein matrix in the wound bed
- Potential to support granulation tissue
- Ability to stimulate the local regenerative process
- Potential to support new vessel formation (angiogenesis)
- Forming a biological microenvironment supportive of cell renewal
- Support of collagen synthesis process
- Potential for tissue perfusion improvement
Why an Autologous/Biological Approach?
In chronic wound care, synthetic wound dressings and dressing materials are indispensable. However, a biological support layer can add a complementary dimension to this standard care.
- Autologous structure: Minimal foreign body reaction risk
- Biological microenvironment: Protein matrix that cells can benefit from
- Sustainable application: Repeatable biological support protocol
- Integration with other protocols: Evaluated together with standard wound care, not instead of it
Clinical Application Process
Evaluation
Before HSP application, the wound is evaluated in terms of size, depth, circulation status, infection presence, and general patient health.
Preparation
A small amount of blood is taken from the patient and HSP is prepared with the standard protocol.
Application
HSP is applied by the physician to the wound bed according to clinical indication.
Follow-up
Follow-up intervals and the number of sessions are planned according to the wound's response.
Important Notes
- HSP does not replace antibiotic or antiseptic treatment
- It can be evaluated after active infection is controlled
- Vascular evaluation should be done before
- Systemic disease management (diabetes control, nutrition, etc.) is maintained concurrently
- Does not replace other standard protocols of wound care